Hydrogels for wound healing applications. Here, Cheng et al.

Hydrogels for wound healing applications. 2 days ago · Chronic and non-healing wounds pose persistent clinical challenges due to infection, inflammation, and impaired tissue regeneration. These hydrogels are designed to respond to specific stimuli, such as pH, temperature, light, and enzyme activity, enabling precise regulation of drug release, antimicrobial activity, and tissue Mar 8, 2024 · It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Feb 7, 2024 · Our research provides an easy but highly effective process for synthesizing a hydrogel film, which is an intriguing choice for wound healing applications without the use of antibiotics. In this study, we tried to introduce the most important hydrogel groups that are effective in healing skin wounds. Dopamine is a known neurotransmitter with antioxidant properties that can be polymerized to form polydopamine (PDA). Conventional hydrogels that work as Feb 18, 2023 · Hydrogels and extracellular vesicle-based therapies have been proposed as emerging therapeutic assets in wound closure. This review offers a comprehensive overview of the current state and potential future advancements in natural hydrogel dressings for wound care, highlighting their critical role in addressing complex and hard-to-heal wounds. Herein, polydopamine is demonstrated as an antioxidant biomaterial. et al. Generally, Figure 7 shows the fabrication of peptide-based hydrogels and the application of such hydrogels in in vivo studies. Hydrogels are appealing dosage forms for biomedical regenerative May 31, 2025 · Stimuli-responsive hydrogels have emerged as a promising class of biomaterials for advanced wound healing applications, offering dynamic and controllable responses to the wound microenvironment. May 5, 2020 · The hydrogel wound dressing is an ideal wound treatment because of its excellent biocompatibility, high moisture resistance and the ability to activate immune cells to speed wound healing. Jun 1, 2023 · Abstract Hydrogels, due to their hydrophilic nature, tunable chemical, mechanical and biological properties, have shown great promises for wound dressing application. Incorporating various biomaterials and nanostructures into the Nov 1, 2020 · Alginate-based hydrogels have been used in wound dressing, tissue engineering, and drug delivery applications for decades. , nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing the performance of resulting composite hydrogels in wound healing applications. Aug 6, 2025 · Graphical abstract Overview of the innovation applications of multidimensional engineering hydrogel in wound healing. All of the abovementioned features of collagen-based hydrogels expedite wound healing, especially in vivo, making them great candidates for wound dressing and skin regeneration applications. Feb 27, 2023 · All of the abovementioned features of collagen-based hydrogels expedite wound healing, especially in vivo, making them great candidates for wound dressing and skin regeneration applications. Methods The review investigates the use of polymer Jul 1, 2025 · Owing to their inherent biocompatibility and biodegradability, hydrogels derived from polysaccharides have emerged as promising candidates for wound management. Untreated skin wounds can pose a serious threat to human health. Jan 7, 2025 · Thus, it is necessary to discuss the application of peptide-based hydrogels in wound healing, specifically in chronic wound healing. 1 There are many kinds of products used for wound management Mar 13, 2025 · Hydrogels have emerged as innovative wound dressings for treating acute and chronic wounds, including burns, diabetic foot ulcers, venous leg ulcers, and pressure ulcers. Jan 1, 2011 · This chapter discusses the use of hydrogels, both natural and synthetic, that can be used for wound healing applications. The intrinsic characteristics of the hydrogels in which the extracellular vesicles (EVs) are loaded allow for overcoming barriers, such as the sustained and controlled release of Jan 1, 2013 · In particular, calcium alginate hydrogels were investigated and used for wound healing applications, due to both the hemostatic properties of the calcium ion and the ability of the gel to serve as a matrix for the aggregation of platelets and erythrocytes [7], [8], [17], [18]. In this review, we present the progress in antibacterial hydrogels for bacteria-infected wound treatment. Our goal was to sum up useful knowledge regarding wound healing and wound treatments, based on creams and hydrogels with various active ingredients. In conclusion, this research provides solutions for the development and application of antimicrobial peptides. Nonetheless, there is a necessity for additional long-term trials tailored to specific wound types and patient characteristics. Feb 13, 2025 · This paper systematically analyzes the existing challenges and explores the future research directions, and emphasizes the potential of multifunctional hydrogels in improving wound healing of diabetes and their clinical application prospects. Chronic wounds are also mentioned, and the focus of attention on infected wounds, burn wounds, and diabetic wounds is discussed. We modify the RHC with . One of the most complex processes in the human body is wound healing, which is achieved through hemostasis, inflammation, proliferation, and remodelling, to recover the integrity and functionality of the damaged area. Mar 10, 2025 · Applications of bioadhesives and bioactive hydrogels in wound management, including tissue adhesion, hemostasis, wound closure, and scarless healing. Conservative wound management frequently falls short in providing an ideal environment for the optimal tissue regeneration, often resulting in extended healing periods and elevated risk of infection and other Nov 27, 2024 · Skin wounds are not only an aesthetic concern but also pose great risks to quality of life and general health. Keywords: hydrogels, diabetic wound, multi-functional, wound dressing Feb 27, 2025 · In this study, a hydrogel material based on porcine gelatin and sodium alginate was synthesized for use as a dressing for chronic wound treatment. However, the biomedical applications of hydrogels are limited currently, due to their poor mechanical properties and insufficient adhesion. However, to restore skin continuity, wound healing is a complicated process that involves the collaboration of a variety of cell types and other mediators. The transparency of hydrogel dressings also allows for easy monitoring of wound healing without removing the dressing. Jul 28, 2021 · This Review Recent Advances in Chitosan and Alginate‐Based Hydrogels for Wound Healing Application Sep 20, 2021 · Hydrogels for wound dressing applications need to adhere firmly to cover the open wound and to provide protective microenvironment for wound healing. May 1, 2025 · Chronic wounds pose significant healthcare challenges. Aug 8, 2025 · Electroconductive, self-healing hydrogels have surfaced as a versatile tool for advanced wound care applications, since they combine classic hydrogels’ moist and biomimetic environment with the dynamic electrical responsiveness that can function as an accelerator of tissue repair processes. Bioactive Polysaccharide-Based Hydrogels Ideal wound dressing materials should actively intervene in wound healing. The various novel techniques in this fascinating area are also being described. Apr 14, 2025 · Abstract Compared to traditional dressings, hydrogel dressings not only protect the wound surface and prevent bacterial infection but also possess excellent moisturizing properties, which can provide an optimal moist environment for wound healing, and exhibit good biocompatibility, making them considered the best wound treatment materials. May 5, 2025 · Hydrogels have a three-dimensional (3D) cross-linked network structure composed of hydrophilic polymers, offering excellent flexibility and biocompatibility (Koetting et al. Several biopolymers have generated interest in a number of biomedical applications. Jul 31, 2023 · This review summarizes the types of chitosan-based hydrogels and their roles and applications in wound healing, providing theoretical references for the development of novel wound healing dressings. Purpose A wound is an incision or injury in the skin or tissues of the body caused by trauma, surgery, or a medical condition. As it can be concluded, almost all biopolymers exhibited promising bioactivity, such as antibacterial and good cytocompatibility. Furthermore, no severe adverse effect was reported for treatment with hydrogel in wound healing. Jul 23, 2024 · Abstract Hydrogels, as an emerging biomaterial, have found extensive use in the healing of wounds due to their distinctive physicochemical structure and functional properties. Hydrogels containing bioceramics can also exhibit anti-inflammatory activity in wound healing applications [111]. In prior work, we developed methodology to prepare hydrogels by crosslinking Mar 26, 2025 · The application background of mussel-inspired materials is based on the unique underwater adhesive ability of marine mussels, which has inspired researchers to develop bionic materials with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. The intrinsic characteristics of the hydrogels in which the extracellular vesicles (E … Feb 17, 2025 · The skin is fragile, making it very vulnerable to damage and injury. We present an overview highlighting the recent achievements in anti‐inflammatory hydrogel dressings, from preparation mechanisms to application methods in wound healing. We further present an overview of the advancements made in using hydrogels for wound healing and offer valuable insights into the production of some hydrogel-based wound dressings. The combination of these elements has given good results in managing chronic and acute wounds. Hydrogels hold significant potential in advancing medical applications, particularly for cutaneous injuries. These smart materials can change their properties in response to stimuli like temperature, pH, ionic strength, and more. • Design strategies of polysaccharide-based hydrogels using various crosslinking approaches are highlighted. 2. Recent advancements in material science have led to the development of honey-containing hydrogels, combining the natural healing properties of honey with the versatile characteristics of hydrogel matrices. In recent years, responsive hydrogels have gained attention for their biocompatibility, adjustability, and environmental responsiveness. Examples of homopolymeric hydrogels include poly (acrylic acid) and PEG hydrogels [70]. Feb 9, 2022 · Moreover, the development of multifunctional self-assembling peptide-based hydrogels that can regulate and remodel the wound immune microenvironment in wound therapy with spatiotemporal control has also been summarized. For instance, the scaffold must be able to faithfully mimic the mechanical structure and properties of the native skin to maintain tissue homeostasis across the injury site. Mar 31, 2023 · The application of alginate-based hydrogels loaded with drugs, growth factors and other bioactive molecules has gained considerable interest from many research groups for their utility in drug delivery and wound healing applications owing to their designing flexibility, versatility in terms of functionalization, tunable intrinsic properties Nov 29, 2021 · The photocrosslinking gelatin hydrogel designed in this study is a potential candidate to enhance wound healing and better skin flap survival. Recently, pullulan has gained Mar 24, 2025 · Exosomes-loaded hydrogels have potential value in wound treatment. We prepared a conjugated sodium alginate/gelatin hydrogel wound dressing incorporating antimicrobial peptides to promote wound healing. Current studies focus on improving hydrogels’ biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Dec 6, 2021 · Light is an attractive tool that has a profound impact on modern medicine. Apr 1, 2024 · This manuscript explores self-healing hydrogels as innovative solutions for diverse wound management challenges. Nov 1, 2024 · The composition, bioactivity, potential of wound healing, and application of some reported biopolymer-based hydrogels have been summarized in Table 1. Jul 1, 2025 · Chronic wounds typically exhibit dynamic variations within the complex wound microenvironment over time. Aug 23, 2024 · Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability to reassemble the extracellular matrix. Oct 31, 2020 · Antioxidants are known to improve the wound healing process and are researched as a therapeutic strategy to treat chronic wounds. However, lack of multifunctionality and low mechanical properties of previously developed hydrogels may limit their ability to support skin tissue regeneration. The nanoengineered system consists of the natural po… Dec 1, 2023 · Abstract Chronic wounds, burns, and surgical incisions represent critical healthcare challenges that significantly impact patient quality of life and strain healthcare resources. This review covers the latest advances in regenerative hydrogels used for wound healing, focusing on their chemical composition, cross-linking Thus, it is necessary to discuss the application of peptide-based hydrogels in wound healing, specifically in chronic wound healing. Mar 12, 2025 · These hydrogels offer numerous advantages, including high moisture retention, biocompatibility, and the controlled release of bioactive compounds, making them highly effective for wound healing applications. Mar 1, 2024 · Currently, there is a rising global incidence of diverse acute and chronic wounds, underscoring the immediate necessity for research and treatment advancements in wound repair. Particularly, light-based photothermal therapy (PTT) and photodynamic therapy (PDT) show great application prospects in the prevention of wound infection and promoting wound healing. 2015). This review explores the classification and characteristics of hydrogel dressings, innovative Jan 26, 2024 · The limited effectiveness of chitosan-based hydrogels in promoting the healing of chronic wounds hampers their widespread application as wound dressings. Categories of anti‐inflammatory hydrogel dressings are based on the specific mechanisms of anti‐inflammatory activities for which hydrogel dressings are created, for example scavenging excessive ROS, sequestering Oct 15, 2022 · Herbal extracts are extensively used for wound healing purposes, individually or in combination with other active agents. The properties of the resulting hydrogels were examined, including gel-fraction Highlights Hydrogels are increasingly used in nursing to provide a moist wound environment, promote healing, and reduce pain. These hydrogels, enhanced with natural biopolymers and inorganic ions, promote cell proliferation, tissue regeneration, and provide a stable, bioactive environment conducive to healing. The review also critically examines the challenges and future directions for HA-based self-healing hydrogels in diabetic wound healing. Recent research shows hydrogels can accelerate healing in partial-thickness burns and pressure injuries by up to 40% compared to traditional dressings. Feb 1, 2025 · The present review summarizes the process of wound healing, technologies adapted in fabrication of hydrogel sponges, application of various polymers (natural and synthetic polymers) in fabrication Apr 3, 2025 · The design of hydrogels for wound care applications, including the treatment of chronic wounds and burns, necessitates several fundamental properties, such as a high water content, the ability to maintain a moist wound environment, gas permeability, and biocompatibility [2]. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. However, the complex nature of wound healing often requires the development of smart hydrogels---intelligent materials capable of responding dynamically to specific physical or chemical stimuli. This chapter also reviews the pH and thermosensitive smart polymers that may be used as wound dressings. Th … Feb 1, 2025 · This results in enhanced wound healing potential compared to the individual components. As the most promising biomaterial, hydrogels are three-dimensional polymeric networks and have attracted intense research attention. Finally, the development prospects and challenges of hydrogel wound dressings are forecasted. Nevertheless, conventional hydrogels can only passively participate in the wound healing process by maintaining the moisture around wound, which limits the wound healing efficacy. Herein, we present a novel biocompatible recombinant human collagen (RHC) hydrogel loading with different MSCs-derived exosomes for promoting wound healing. The therapeutic effect of traditional hydrogels is limited, while multifunctional composite hydrogels show greater In conclusion, hydrogels hold immense promise as versa-tile materials with diverse applications across various fields, including biology, biomedical technology, biotech-nology, nursing, and wound healing. To overcome this deficiency, researchers have explored the use of therapeutic drugs in conjunction with chitosan-based hydrogels to enhance their efficacy. Nov 29, 2023 · The use of 3D bioprinted cellulose-based wound dressings has potential benefits for managing chronic wounds, burns, and painful wounds by promoting wound healing and reducing the risk of infection. Mar 1, 2025 · Among various biomaterials, antibacterial hydrogels are one of the most recommended groups due to their ability to load antibacterial drugs and cover wounds while maintaining a moist environment. Jun 1, 2023 · Here we describe recent studies on hydrogels for wound healing applications with a strong focus on the interplay between the fabrication method used and the architectural, mechanical, and biological performance achieved. The hydrogels were covalently cross-linked using polyethylene glycol diglycidyl ether (PEGDE 500), and the interaction between the components was confirmed via FTIR. In this study, a multifunctional hydrogel drug delivery system (HA@TA-Okra) was constructed through the integration of hyaluronic acid methacrylate (HAMA) matrix with tannic acid (TA) and okra extract. They create an optimal healing environment for wounds by providing numerous advantages, including moisturization, exudate absorption, antimicrobial properties, controlled drug release, and non-adherence to the wound May 13, 2025 · Hydrogels keep the wound bed just moist enough to support cellular activity while also cooling the skin, offering pain relief. • Advances in the development of hydrogels derived from diverse natural polysaccharides This systematic review revealed that hydrogel dressings are effective in treatment of chronic wounds. Nov 1, 2023 · Homopolymer hydrogels have been used in a variety of applications, such as drug delivery, tissue engineering, and wound healing. Mar 1, 2025 · Highlights • An overview of the use of natural polysaccharide-based hydrogels for hemostasis and wound healing is provided. The ideal wound dressings should have the characteristics of non-toxicity, retaining moisture, and promoting wound healing. Chitosan is popular in tissue engineering applications due to its antimicrobial nature and biocompatibility [36]. We concluded that both preparations have application in preventing infections and promoting healing, but their efficacy is clearly conditioned by the type, depth, severity of the wound and patient Among these, multifunctional hydrogels have shown considerable potential in promoting skin wound healing as a type of wound dressing material. In addition, hydrogels have shown attractive advantages in the field of wound dressings due to their excellent biochemical effects Nov 26, 2024 · Hydrogels are highly versatile biomaterials that have revolutionized various fields of biomedicine, including wound healing, tissue engineering, drug delivery, and regenerative medicine. For instance, the controlled release of silicon (Si) ions from bioceramic particles that were encapsulated in gelatin/PCL nanofibers reduced inflammation while increasing angiogenesis, collagen deposition, and re-epithelization [112 Feb 1, 2019 · They are also capable of interacting with the wound bed in order to facilitate and accelerate the healing process. Incorporating various biomaterials and nanostructures into the Aug 9, 2016 · These all-polysaccharide composite hydrogels may work as promising scaffolds in wound healing applications to provide supporting networks and to promote cells adhesion, growth, and proliferation. May 6, 2025 · As for the complexity of chronic wounds, biocompatible hydrogel dressings can be employed to regulate the microenvironment and accelerate wound healing with their controllable physical and chemical properties. May 20, 2024 · The natural physiological response to skin injury is wound healing. This review systematically examines the progress in the application of multifunctional hydrogels in skin wound healing. Nov 17, 2023 · The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. Feb 18, 2023 · Hydrogels and extracellular vesicle-based therapies have been proposed as emerging therapeutic assets in wound closure. In response to these pressing needs, the field of wound healing has witnessed a radical advancement with the emergence of functional hydrogel-based dressings. Mar 4, 2023 · The high-water retention capacity of hydrogels makes them potent candidates for wound dressings as they provide a moist environment in the wound and remove excess wound fluid, thereby accelerating wound healing. Wound management is one such area where management of cuts, ulcers and sores needs dressings which help in promoting rapid wound healing in order to obtain both functional and cosmetic results. Hydrogel dressings help maintain a moist environment, crucial for wound healing. Initially, the structure and composition of the skin are introduced. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Nanoparticle-infused hydrogels have emerged as next-generation wound dressings, offering synergistic benefits by combining the moisture-retentive, biocompatible properties of hydrogels with the multifunctional therapeutic capabilities of nanoparticles. Advanced dressings such as hydrogels are designed to maintain a moist environment at the site of application and due to high water content are ideal candidates for wound management. This review initially looks at wounds in general, treatment strategies employed, their impact on health and the economy, and the need for suitable therapies. Also, we discuss the benefits of using creams and ointments and their role in wound healing and highlighted the role of each type of product in the wound healing process based on their unique properties. This review focuses on the research status and Jan 5, 2024 · Additionally, hydrogels can be successfully integrated with a plethora of biologically active components (e. Feb 15, 2021 · Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix (ECM) and ability to provide a moist environment. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus is able to form non-covalent forces on a variety of This article reviews the most widely used antibacterial gel dressings for wound healing in recent years and focuses on the application of an environmentally responsive intelligent hydrogel delivery system. Oct 17, 2024 · Background Wound healing represents a complex biological process, critically important in clinical practice due to its direct implication in a patient’s recovery and quality of life. Overall, this review sheds light on the future clinical and practical applications of self-assembling peptide-based hydrogels. Mar 8, 2024 · It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Finally, the development prospects and challenges of hydrogel wound dressings are discussed. Moreover, hydrogels can be made to match a range of therapeutic requirements for materials used in wound healing through specific functional modifications. This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. At the first phase of wound healing, it is important for hydrogel to act as hemostatic material to stop bleeding rapidly. Three-dimensional polymer network hydrogels have broad application prospects in skin wound dressings due to their unique properties and structure. This study summarizes the current knowledge acquired on the preparation, functionalizing, and application of different kinds of polysaccharide-based hydrogels enriched by herbal extracts for different wound healing applications. Hydrogels have emerged as promising materials for wound healing due to their unique physical and chemical properties. Recently, various nanomaterials have been introduced into hydrogel networks to prepare functional nanocomposite hydrogels. develop a microenvironment-feedback hydrogel to achieve homeostatic Mar 12, 2025 · Honey has long been recognized for its medicinal properties, particularly in wound healing. Aug 1, 2024 · Meanwhile, the antimicrobial peptide showed great antimicrobial activity and biocompatibility. In this review, the authors likely delve into the application of rational design principles to enhance the efficacy and performance of hydrogels in promoting wound healing. Finally, we present new wound healing devices that are based on new technologies such as combining smart hydrogels with physical therapies. Hydrogels have developed a diverse range of biomedical and biopharmaceutical applications, owing to their large water content, biocompatibility, tunable Sep 17, 2021 · Qu, J. Hydrogel-based wound dressings have garnered significant attention in the field of wound care. Their unique properties, such as high water content, biocompatibility, and tunable mechanical properties, make them ideal for various medical applications. • The mechanisms of wound healing and hemostasis are summarized. Responsive In addition, we conclude and provide an outlook on the application of hydrogel-based dressings in wound healing, with the aim of further enhancing their ability to promote wound healing. Jan 1, 2011 · Healthcare is an essential aspect of human survival. Here, Cheng et al. Recent advances report the automatic restoration of materials after mechanical disruption through Dec 1, 2024 · This review paper presents a comprehensive classification of injectable self-healing hydrogels commonly used in chronic wound repair and provides a detailed analysis of the various applications of injectable self-healing hydrogels in treating chronic wounds, thereby illuminating this rapidly evolving field. Aug 24, 2021 · Furthermore, applications of hydrogel wound dressing for the treatment of different types of wounds such as incisional wound and the excisional wound are summarized. Oct 1, 2025 · Skin wound healing involves complex biological processes such as inflammation, cellular proliferation, and tissue repair. The composition The role of hydrogels in improving gas exchange and oxygen supply along with absorption of wound secretions and temperature regulation and reduction of infectious agents on the wound is known. Oct 15, 2022 · Herbal extracts are extensively used for wound healing purposes, individually or in combination with other active agents. Jan 5, 2024 · The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. This Jun 22, 2025 · The graphical abstract illustrates the role of hydrogel-based flexible materials in advancing biomedical applications, including wound healing, point-of-care diagnostics, smart patches, and wearable Aug 5, 2025 · Overview of the essential hydrogel characteristics for wound healing applications Injectable hydrogels have attracted considerable interest in biomedical applications, such as wound dressings, drug delivery, tissue engineering, and regenerative medicine. Addressing antibiotic resistance and tailored wound care, these hydrogels exhibit promising outcomes, including accelerated wound closure and tissue regeneration. Over the past decade, an increasing Jan 28, 2025 · Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in the microenvironment of wound infection to promote wound healing. Advancements in multifunctional hydrogels with controlled drug release, antimicrobial properties, and real-time wound 4. Dec 25, 2024 · Due to its self-healing capabilities, these hydrogels offer a customized therapeutic approach for motional diabetic wounds. Natural polysaccharides, such as chitosan and pullulan, have been used for preparing hydrogels in various biomedical applications. These polymeric networks provide a moist wound environment, promote cellular migration, and offer antimicrobial properties, being recognized as superior to conventional dressings. This article overviews the wound healing process and current therapeutic challenges, surveys the biomedical applications of MOFs and hydrogels individually, and presents their preparation methods. This review provides a comprehensive analysis of the benefits, mechanisms, and challenges associated with the use of regenerative hydrogels in the treatment of skin wounds. This process ultimately results in tissue regeneration and the restoration of skin barrier function. Nov 1, 2024 · This work first summarizes the skin wound healing process and its influencing factors, and then systematically articulates the multifunctional roles of hydrogels based on biological macromolecules (polysaccharides and proteins) as dressing in addressing bacterial infection, hemorrhage and inflammation during wound healing. Jan 1, 2025 · This review aims to summarize recent advancements and applications of hydrogels, including those with intrinsic therapeutic properties and hydrogel-based drug delivery systems, in the treatment of refractory wounds. Hydrogels, which are commonly polymer-based and swell in water, have been proposed as potential remedies due to their ability to provide a moist environment that facilitates wound healing. Moreover, we review different categories of additives which can enhance wound regeneration using 3D hydrogel dressings. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing. g. Oct 1, 2024 · Furthermore, we propose the challenges and future perspectives of natural hydrogels in practical applications. In this review, we summarize the recent approaches in the chemical and physical preparation and the application of alginate hydrogels in wound dressings. May 12, 2025 · For wound healing applications, the manufacturing process of hydrogels must consider several factors to ensure optimal functionality of the scaffold. Apr 1, 2018 · We report injectable nanoengineered hemostats for enhanced wound healing and tissue regeneration. However, a comprehensive review of their clinical application for enhancing chronic wound healing is lacking. Hydrogels with a 3D network structure have a series of excellent properties, such as an excellent hydrophilicity, good water retention, and biocompatibility properties, gaining them much attention for wound healing applications [6, 7]. auw hs xp a4 sbcnqn kxnvz syyg g03n uhd oo