Nipagin m solubility. In the event of contact, eyes should be flushed and .

Nipagin m solubility. It is a short-chain paraben for higher water solubility. See full list on chembk. Follow the links above to find out more about the data in these sites and their terms of usage. Jan 1, 2022 · nipagin p - Content determination Authoritative Data Verified Data measured by high performance liquid chromatography (General 0512). Microorganisms MIC level (%) Gram Negative Bacteria Pseudomonas aeruginosa 0. Methylparaben is known by various common names, including Methylparaben, Methaben, Nipagin M, and Methyl p-hydroxybenzoate. Nipagin M Sodium is used in all kinds of personal care products. This product is freely soluble in most oils, waxes, fatty alcohols, but has relatively low solubility in water Abstract Aza-porphyrinoids exhibit distinct spectral properties in UV-Vis, and they are studied in applications such as photosensitizers in medicine and catalysts in technology. This product is highly soluble in cold water for ease of addition. According to the chromatographic conditions under the content determination item, 20 ml of the Nipagin M Sodium shows high solubility in cold water, low order of toxicity and good biodegradability at environmental concentrations. It is Methylparaben (methyl 4-hydroxybenzoate) acts as a methylparaben preservative used in a variety of cosmetics products such as shower gels, shampoos, etc. Nipagin® A is a water-soluble preservative. It is used in hair conditioners, color cosmetics, antiperspirants & deodorants, bar- and liquid soaps. It offers broad spectrum of activity against bacteria and fungi. Methylparaben Sodium | C8H7O3Na or C8H7NaO3 | CID 23663626 - structure, chemical names, physical and chemical properties, classification, patents, literature Oct 26, 2025 · Methylparaben (CAS 99-76-3) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices Methylparaben is a 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. Protective equipment including gloves, goggles, and respirators should be used when handling. Find A&C by Aceto's pharmaceutical excipient solutions for Nipagin M to address your drug formulation challenges (e. In the case of bacteria, parabenes are more effective against gram-positives as compared to gram-negative bacteria. improved solubility, drug delivery, bioavailability, taste masking, controlled release, stability, etc. 15 EC Number: 202-785-7 Find suppliers of pharmaceutical excipients such as Controlled & Modified Release Agents used in Nipagin M formulations to address your drug formulation challenges (e. Methylparaben United States Pharmacopeia (USP) Reference Standard; CAS Number: 99-76-3; Synonyms: Methyl 4-hydroxybenzoate,p-Hydroxybenzoic acid methyl ester,Methyl paraben,NIPAGIN; Linear Formula: HOC6H4CO2CH3 at Sigma-Aldrich Nipagin M Sodium is highly soluble in water and so easily incorporated into cosmetic formulations. Aug 18, 2022 · View technical datasheet of Nipagin® M Sodium. chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler; Methanol -1% glacial acetic acid (60 : 40) as mobile phase, the detection wavelength was 254mn. Apr 3, 2025 · View technical datasheet Nipasol® M. ,Ltd's pharmaceutical excipient solutions - Povidone for Nipagin M to address your drug formulation challenges (e. It aims to ensure safe handling and use of the Find suppliers of pharmaceutical excipients such as Emulsifying Agents Agents used in Nipagin M formulations to address your drug formulation challenges (e. with Nipagin M, Nipagin A or Nipabutyl exhibit increased activity compared with individual esters. It is classified as causing eye irritation. 02 Methylparaben is a synthetic preservative commonly used in cosmetics and personal care products. This product is freely soluble in most oils, waxes, fatty alcohols, but has relatively low solubility in water. 4 Liquid paraffin 0. Nipagin® M Sodium is designed for preservation of a wide range of cosmetics and toiletries. Combinations of p- Hydroxybenzoic acid esters, e. The use of appropriate peripheral substituents allows the modulation of their physicochemical properties. Clariant SDS NIPAGIN M Indonesia English Material Safety Data Sheet Page 1 NIPAGIN M Substance key: 000000051881 Version : 1 - 11 / RI Revision Date: 09. Nipagin® A shows good biodegradability at Applications Typical use concentrations of Ethylparaben is 0. Ideal para farmacéuticos. Incorporation Ethylparaben is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility in Find suppliers of pharmaceutical excipients such as Thickeners and Stabilizers Agents used in Nipagin M formulations to address your drug formulation challenges (e. 3 %. Nipasol™ M is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries and topical pharmaceuticals. Nipagin® M Sodium is suitable to preserve both rinse- off and leave- on formulations. with Nipasol M, Nipagin A or Nipabutyl exhibit increased activity compared with individual esters. Nipagin™ M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries, and topical pharmaceuticals. Find suppliers of pharmaceutical excipients such as Solubilizers Agents used in Nipagin M formulations to address your drug formulation challenges (e. Find Faran Shimi Pharmaceutical's pharmaceutical excipient solutions - Polyvinylpyrrolidone for Nipagin M to address your drug formulation challenges (e. 03. com. chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler; Methanol -1% glacial acetic acid (60 : 40) as mobile phase, the detection wavelength was 254nm. Incorporation Nipagin®M 200 mesh is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility in water. Find Anhui Sunhere Pharmaceutical Excipients Co. Find suppliers of pharmaceutical excipients such as Rheology Modifiers Agents used in Nipagin M formulations to address your drug formulation challenges (e. Benefits High solubility in cold water Broad spectrum of activity against bacteria and fungi Low order of toxicity Effectiveness at Nipagin™ M is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries and topical pharmaceuticals. It is suitable for both rinse-off and leave-on formulations. Methyl P-Hydroxybenzoate, MP Biomedicals—The methyl ester of p-hydroxybenzoic acid. Methyl 4-hydroxybenzoate, 99% from Thermo Scientific Chemicals. Aug 12, 2022 · Zinc (II), Palladium (II), and Metal-Free Phthalocyanines Bearing Nipagin-Functionalized Substituents against Candida auris and Selected Multidrug-Resistant Microbes Find Kerry's pharmaceutical excipient solutions - Hydroxypropyl Methylcellulose for Nipagin M to address your drug formulation challenges (e. Aug 18, 2022 · View technical datasheet of Nipagin® A Sodium. Nipagin® A Sodium Efficacy and application: Good water solubility; INCI Name: SODIUM ETHYLPARABEN Find suppliers of pharmaceutical excipients such as Fillers, Diluents & Binders Agents used in Nipagin M formulations to address your drug formulation challenges (e. It is a water-soluble preservative (short-chain paraben in sodium salt form) used in all kinds of personal care products. However, NIST makes no warranties to that Apr 30, 2024 · Nipagin - Content determination Authoritative Data Verified Data measured by high performance liquid chromatography (General 0512). 20 Jan 16, 2014 · Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. Its chemical formula Get instant access to Nipagin M technical datasheet. It occurs naturally in several fruits, particularly in blueberries. Methylparaben is widely used as a preservative in cosmetics, skincare products, personal care products, and pharmaceuticals to prevent the growth of microorganisms and increase product shelf life. with Nipagin® M, Nipagin® A or Nipabutyl® exhibit increased activity compared with individual esters. 1980 yılında Cengiz Tuncel, Şelale Kimya' yı devralmış ve 2006 yılında hammadde ithalatı ve ihracatı amacıyla ATAMAN Kimya Ltd' yi kurmuştur. Ş adını almıştır. 13 Water 25 °C 0. The product may form explosive dust clouds and proper ventilation is required. g. May 9, 2021 · Uniphen P-23 Nipagin M E218 Function or Role It is used as an antimicrobial preservative. Showcasing potential for increased solubility through hydrogen bonding interactions. This product is effective against bacteria, molds and yeast. Increased antimicrobial activity at alkaline pH. Shop Methyl 4-hydroxybenzoate, 99% at Fishersci. Methylparaben serves as a pheromone for a variety of insects [3] and is a component of queen mandibular pheromone. Related substances take this product, add the mobile phase to dissolve and dilute the solution containing lm g per lm l as the test solution; Take lm l with precision and put it in a 100ml measuring flask, the mobile phase was diluted to the scale, and the solution was used as a control solution. Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. Chemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters. Uses Nipagin M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals. It has stability over a broad pH-range and global acceptance in personal care applications. It inhibits yeast growth and is typically used as a preservative. Jul 4, 2018 · Methylparaben is used in allergenic testing. It is present naturally in cloudberry, white wine and bourbon vanilla. [4][5] Dec 9, 2013 · Nipagin M is the best water soluble short-chain Paraben. It exhibits low order of toxicity and effectiveness at low concentrations. 55% In addition to the Thermodynamics Research Center (TRC) data available from this site, much more physical and chemical property data is available from the following TRC products: SRD 103a – Thermo Data Engine (TDE) for pure compounds. This is illustrated by the following table which shows the minimum inhibitory concentration (MIC) of Nipagin® M against examples of different groups of microorganisms. Other names: Benzoic acid, 4-hydroxy-, methyl ester; Benzoic acid, p-hydroxy-, methyl ester; p-Carbomethoxyphenol; p-Hydroxybenzoic acid, methyl ester; p-Methoxycarbonylphenol; Abiol; Maseptol; Methaben; Methyl chemosept; Methyl p-hydroxybenzoate; Methyl Butex; Methyl Parasept; Methyl 4-hydroxybenzoate; Methylben; Metoxyde; Moldex; Nipagin The sodium salt provides improved solubility in water compared to standard methyl 4-hydroxybenzoate. Solubility The solubility of Nipagin® M in different solvents is illustrated in the following table: Solvent % (w/w) Water 10 °C 0. improved solubility, drug delivery, bioavailability, taste masking, stability, etc. This document provides a safety data sheet for Nipagin M, which is a white, odorless crystalline powder used as a preservative. No heating stage required for incorporation, thus saving energy and plant occupancy. The sheet lists hazards, composition, first aid measures, firefighting guidance, handling and storage instructions, and exposure control recommendations including personal protective equipment. Ataman Kimya 2009 yılında Cengiz Tuncel tarafından bir sonraki nesile devredilmiştir ve 2020 yılında ATAMAN Kimya A. It is important to note that, whilst the aqueous solubility in alkaline solution is high, if the pH of the formulated product is acidic the sodium salt reverts to the ester and the low solubility is regained. The low aqueous solubility does not affect the microbiological efficacy of the esters. 201 0 0 543KB Read more Uses Nipagin M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals. It is the most frequently used antimicrobial preservative in cosmetics. Exhibiting varying degrees of solubility under different pH conditions. Its primary function is to extend the shelf life of these products by inhibiting the growth of harmful bacteria and molds. In the event of contact, eyes should be flushed and Ethylparaben. This document provides a safety data sheet for Nipagin M, which is identified as methyl-4-hydroxybenzoate. ). with Nipasol M, Nipagin M or Nipabutyl exhibit increased activity compared with individual esters. Language selection | Public Health 1980 yılında Cengiz Tuncel, Şelale Kimya' yı devralmış ve 2006 yılında hammadde ithalatı ve ihracatı amacıyla ATAMAN Kimya Ltd' yi kurmuştur. 30%, O 31. com The Sodium Parabens, like Nipagin M Sodium have several additional advantages: Nipagin M sodium is highly soluble in cold water for ease of addition. Shop Methyl P-Hydroxybenzoate, Ficha técnica detallada de Nipagín y Nipasol: propiedades, usos, dosificación, incompatibilidades y ejemplos de formulación. Phthalocyanine and sulfanyl porphyrazine octa-substituted with 4- (butoxycarbonyl)phenyloxy moieties were Clariant, a world leader in specialty chemicals would like to remind you that our single active parabens, sodium salts and solid blends that include the following product lines: Nipastat®, Nipasept® and Nipasept® Sodium, Nipagin®, Nipagin Sodium®, Nipasol® and Nipasol Sodium® have been tested to the respective USP monographs but Clariant is not certifying these products as USP Applications Typical use concentrations of PROPYLPARABEN is 0. Methyl 4-hydroxybenzoate has antimicrobial and antifungal functionality and is commercially used as a preservative in the food, cosmetic and pharmaceutical industry. Notes Go To: Top, UV/Visible spectrum, References Data from NIST Standard Reference Database 69: NIST Chemistry WebBook The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. It is a long-chain paraben for higher efficacy & less water solubility. Methyl 4-hydroxybenzoate, also called methyl paraben or nipagin, comprises the ester of p -hydroxybenzoic acid. Nipagin M So-dium is suitable to preserve both rinse- off and leave- on formulations. Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) is an anti-fungal agent often used in a variety of cosmetics, personal-care products and food preservatives. The major benefit offered by the sodium salts is their high solubility in cold water, thereby enabling the introduction of parabens without heating or pre-dissolving in solvents. Find suppliers of pharmaceutical excipients such as Parenteral Agents used in Nipagin M formulations to address your drug formulation challenges (e. Jan 16, 2014 · Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. Methyl Paraben (Nipagin) boosts histamine, aids immunity; used as antimicrobial, preservative, and flavor; found in some fruits, wines, and vanilla. NIST subscription sites provide data under the NIST Standard Reference Data Program, but require an annual fee to access. The purpose of the fee is to recover costs associated with the development of data collections included in such sites. Kingdom Organic compounds Super Class Benzenoids Class Dec 9, 2013 · Nipagin A is a short-chain paraben for higher water solubility. . 1 Water 100 °C 6. Find Boai NKY Pharmaceuticals Ltd's pharmaceutical excipient solutions - Polyvinylpyrrolidone for Nipagin M to address your drug formulation challenges (e. These are aromatic compounds containing a benzoic acid, which is esterified with an alkyl group and para-substituted with a hydroxyl group. The nimodipine shows the highest solubility in pure PEG 400 and its lower so-iv 0 Resumen lubility in pure ethanol. SRD 103b – Thermo Data Engine (TDE) for pure compounds, binary mixtures and chemical reactions SRD 202 – Web Thermo Tables (WTT), "lite" edition SRD 203 The solubility of Nipagin A increases greatly as the temperature of the water rises. It provides a broad spectrum of activity against bacteria & fungi. It is a propyl 4-hydroxybenzoate and is used as a preservative. Find Nanjing Well Pharmaceutical's pharmaceutical excipient solutions - Castor Oil Excipient for Nipagin M to address your drug formulation challenges (e. 1 – 0. Incorporation PROPYL PARABEN is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility in Dec 9, 2013 · Nipagin A Sodium is a highly water-soluble short-chain paraben in sodium salt form. Parabenes are more effective against moulds and yeast but they also show a broad spectrum of antimicrobial activity. Dec 9, 2013 · Nipagin M is the best water soluble short-chain Paraben. Incorporation METHYL PARABEN is freely soluble in most oils, waxes, fatty alcohols, but have relatively low solubility Nipagin® M is stable up to 80 °C. CAS Registry Number: 99-76-3 CAS Name: 4-Hydroxybenzoic acid methyl ester Additional Names: methyl p-hydroxybenzoate Trademarks: Nipagin M; Tegosept M; Methyl Chemosept; Methyl Parasept (Tenneco) Molecular Formula: C8H8O3 Molecular Weight: 152. Nipagin M Sodium is highly soluble in water and so easily incorporated into cosmetic formulations. Therefore a concentrate may be made up by heating an appropriate quantity of water to 60- 100 °C prior to addition of Nipagin A. It is suitable to preserve both rinse-off and leave-on formulations. Synonym (s): Methyl 4-hydroxybenzoate, p-Hydroxybenzoic acid methyl ester, Methyl paraben, NIPAGIN Linear Formula: HOC6H4CO2CH3 CAS Number: 99-76-3 Molecular Weight: 152. It was found that the solubility of nimodipine increases as the mass fraction of PEG 400 increases. Nipagin® M exhibits microbiostatic activity against a wide range of bacteria, yeast and mould. 15 Percent Composition: C 63. It is a pheromone in wolves produced [clarification needed] during estrus associated with the behavior of alpha male wolves preventing other males from mounting females in heat. Available in 100 g Find suppliers of pharmaceutical excipients such as Coating Systems & Additives Agents used in Nipagin M formulations to address your drug formulation challenges (e. pH stability Trade Names: Aseptoform P, Betacide P, Betacine P, Bonomold OP, Chemacide pk, Chemocide pk, Nipagin P, Nipasol, Nipasol M, Nipasol P, Nipazol, Paraben, Parasept, Paseptol, Preserval P, Propagin, Propyl aseptoform, Propyl butex, Propyl chemosept, Propyl chemsept, Propyl parasept, Protaben P, Pulvis conservans, Solbrol P, and Tegosept P. It has a role as a plant metabolite, an antimicrobial food preservative, a neuroprotective agent and an Applications Typical use concentrations of METHYL PARABEN is 0. pH stability Find Boai NKY Pharmaceuticals's pharmaceutical excipient solutions for Nipagin M to address your drug formulation challenges (e. Methylparaben appears as a white, odorless, crystalline powder and is known for its efficacy and cost-effectiveness in preventing microbial contamination. Your institution may already be a subscriber. The solubility of Nipagin A increases greatly as the temperature of the water rises. 25 Water 80 °C 3. Dec 9, 2013 · Nipagin A is a short-chain paraben for higher water solubility. Methyl paraben is an effective inhibitor of molds, yeasts and other microorganisms that commonly grow on food products; Sodium Methylparaben is frequently used as a food preservative. 2 Acetone 39 Methanol 37 Ethanol 32 Propylene Glycol 26 Glycerol 3. 15%, H 5. ChemSpider record containing structure, synonyms, properties, vendors and database links for Methyl Paraben, 99-76-3, Methylparaben, LXCFILQKKLGQFO-UHFFFAOYSA-N Jan 16, 2014 · Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. Dec 9, 2013 · Nipasol M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics and toiletries. 3 Vegetable oils (arachis) 2. Dec 9, 2013 · Nipasol M is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics and toiletries. Generally more soluble in polar solvents due to its structural features. Applications Typical use concentrations of Nipasol® M is 0. Find suppliers of pharmaceutical excipients such as Co-Processed Excipients Agents used in Nipagin M formulations to address your drug formulation challenges (e. 434 zjdyvzz ge qvdz cfy jh rqg uxu8wqvr3 xooz wu8u