Pluronic f127 properties. 5-2%) and of mixed gels containing Pluronic (10-17.
Pluronic f127 properties. from publication: Applications of thermo-reversible Pluronic F-127 gels Potential degradation by sonication Wang et al. [8 Moreover, Pluronic F-127 hydrogel has favorable properties such as non-toxicity, biocompatibility, and biodegradability. Pluronic F-127 (PF-127) hydrogel is a versatile biomaterial with promising applications in drug delivery, tissue engineering, and regenerative medicine. Pluronic F-127 can encapsulate poor water-soluble drugs and administrate the medicine to Apr 10, 2018 · The purpose of this study was the evaluation of the impact of sterilisation conditions on selected rheological properties of Pluronic F-127-based oph- Dec 3, 2012 · The PEO segment of Pluronic F 127 is highly hydrophilic, while the PPO segment of Pluronic F 127 is hydrophobic [14], [20]. In this study, we reported the hyaluronic acid (HA) on supramolecular structure of Pluronic F-127 (PLF-127) and/or Pluronic F-108 (PLF-127) hydrogels, as well as their effects on release mechanisms, looking forward their application as lidocaine (LDC) drug-delivery systems in arthroplastic surgeries … Mar 3, 2010 · CONCLUSION: From the above discussion it is conclude that Pluronic F127 can be considered as a suitable thermoreversible polymer for the delivery of drug into various body cavities. A rheological study of Pluronic aqueous sols (10-35%), Noveon gels (0. The mucoadhesive properties of Pluronic and Noveon gels were compared by a force of detachment test. PF-127 has antiadhesive activity that prevents bacterial adhesion by creating a hydrated layer on the bacterial surface. [8 Jan 1, 2016 · Pluronic F127 hydrogel with 25%w/v concentration was selected as bioink due to its fast gelation at 37 °C (5 min), suitable viscoelastic properties (G’= 16500 Pa at 37 °C), pseudoplastic behaviour and fast viscosity recovery after shearing (approximately 5 s). Pluronic F-127-modified nanomicelles incorporating bufalin (an anti-tumor agent) were developed with thermal and redox-responsive properties. May 1, 2025 · Mechanical and rheological properties of Pluronic F127 based-hydrogels loaded with chitosan grafted with hyaluronic acid and propolis, focused to atopic dermatitis treatment Pluronic ® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. Two of the polymer gel dosimeters (PAGAT and VIP) containing the Pluronic F-127 matrix allowed for some proper dose response for radiotherapy dosimetry (a response to a dose range of e. Jun 1, 2022 · New polymeric systems are constantly developed for novel biomedical applications. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. Nov 23, 2024 · In this context, the present study was focused on thermoresponsive Pluronic F127-based hydrogels incorporating bioactive molecules from natural sources, as potential injectable systems with antioxidant properties. In this work, macroporous brushite cements were fabricated through foaming of the cement paste, using two different synthetic surfactants, Tween® 80 and Pluronic® F‐127. Biochem/physiol Actions Pluronic ® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. The toxicity data of the polymeric series is reviewed. 5%) was conducted at different temperatures (15-35 degrees C). Nov 7, 2024 · I. Download Table | Physical properties of Pluronic F68 and F127 block copolymers. In general, poloxamers are composed of white, waxy, free-flowing granules that are practically odorless and tasteless (23). 2023 Apr 25;12 (9):1760. The composite was prepared by facile physical mixing of pluronic F-127 (PF) and silk fibroin (SF) in an aqueous solution. Jan 23, 2013 · Triblock copolymer Pluronic F127 has been used to form composites with zein, a corn protein and coproduct of the bioethanol industry, to alleviate its natural brittleness. It comprises a focal hydrophobic (polypropylene oxide) chain and two terminal hydrophilic poly (ethylene oxide) chains. R. The release of benzoic acid and related compounds from Pluronic F-127 (PF-127) gels has been studied in an in vitro release model. Pluronic F127 (PF127) is a tri-block copolymer with surface-active properties. from publication: Encapsulation of Curcumin in Pluronic Block Copolymer Micelles for Drug Delivery Applications | We Sep 1, 2012 · Pluronic F-127 (also known as Poloxamer 407 or PF-127) is a hydrophilic thermoreversible hydrogel system that has been used for drug delivery across different routes of administration. Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO Characteristics and properties of poloxamer 407 (pluronic F-127) Poloxamer 407 (PF-127) is a nonionic surfactant composed of polyoxyethylene-polyoxypropylene copolymers in a concentration ranging from 20-30%. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG). However, selecting the appropriate hydrophobic group for modification is laborious. 5 a, it is observed that pure Pluronic F-127 hydrogel shows decrease of viscosity with the increase of shear rate. Download scientific diagram | Chemical structure of Pluronic F-127 (a, ethylene oxide portion b, propylene oxide portion). Sep 22, 2025 · Chemsrc provides Pluronic F-127 (CAS#:721929-01-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Moreover, toxicity correlated with the sonolytic degradation of the polymers Applications of Pluronic F-127: A main advantage of pharmaceutical biotechnology includes the synthesis of optimal polymers which can increase the bioavailability and thermostability of incorporated biotherapeutic agent. 3 PF-127 is a non-ionic surfactant made of ethylene oxide and propylene oxide blocks Artificial skin. In both minimum essential medium (MEM) and MEM with added fetal bovine serum (MEM-FBS), the gel-phase boundary shifts to lower temperatures and concentrations as In this context, Pluronic F127 (PF127) has a major role as it was shown to have exceptional versatility, once it holds unique gelation properties, as it is thermoreversible and is liquid in lower temperatures, and changes to gel in higher temperatures. [8 Oct 1, 2023 · Quaternized chitosan / Pluronic F127 thermosensitive hydrogel with high antibacterial properties for wound dressing Kaiting Cheng a , Yiming Fang a , Liang Bai a , Feng Gui a , Junchi Ma b , Huimin Gao a , Yadong Zhao c , Xingtao Xu a Show more Add to Mendeley Sep 15, 2020 · The results shed light on structural properties of curcumin solubilized pluronic F127 solutions and hydrogels; and how some of the therapeutic properties of curcumin are manifested in a state of encapsulation by pluronic F127 micelles. When drugs are encapsulated as pluronic Nov 22, 2023 · We have also presented a detailed explanation of the structure and properties of Pluronic® polymers. 1, 2 It is Jul 15, 2020 · Properties of pluronics P123-F127 micellar system and influences of salt and tea tree oil (TTO) on them are investigated. [8 Biochem/physiol Actions Pluronic ® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. PLURONIC F-127 Characteristics and properties Pluronic® F-127 (Basf, Ludwigshafen, Germany), also known as poloxamer 407 (P407), (copolymer polyoxyethylene106-polyoxypropylene70- polyoxyethylene106) contains about 70% ethylene oxide, which contributes to its hydrophilicity (25). 5-2%) and of mixed gels containing Pluronic (10-17. Jun 5, 2023 · Properties of Pluronic F68 and F127 micelles interacting furosemide from coarse-grained molecular simulations as validated by experiments Aug 1, 2005 · The effect of Pluronic F-127 on the mucoadhesive property of Noveon was investigated. 5 b shows the viscosity versus shear rate of Pluronic F-127 hydrogel loaded with 65 wt. Sep 10, 2025 · Pluronic® F-127 is a nonionic surfactant that is 100% active and relatively non-toxic to cells, and frequently used with dye AM esters to improve their water solubility. # 20052) and 10% Pluronic® F-127 water solution (Cat. The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene May 25, 2023 · Abstract Pluronic F-127 (PF-127) hydrogel is a versatile biomaterial with promising applications in drug delivery, tissue engineering, and regenerative medicine. They are attractive for several biomedical applications because of their non-toxicity, biocompatibility, and heat Apr 1, 2020 · Pluronics P123 and F127 mixed micellar system has been studied extensively for drug delivery applications because of its non-toxic nature, good solubilization capacity of lipophilic substances and Pluronic® F-127 may also be useful for dispersing other lipophilic probes. Pluronic F127 is a difunctional block copolymer surfactant terminating in primary hydroxyl groups. This comprehensive review provides an in-depth exploration o … Crl-8131 | C5H10O2 | CID 24751 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety The antimicrobial properties of Pluronic F127 gels are very modest even by adding chitosan, lysozyme, or ZnO nanoparticles. Home Synthesis and characterization of Pluronic F-127-coated titanium dioxide nanoparticles synthesized from extracts of Atractylodes macrocephala leaf for antioxidant, antimicrobial, and anticancer properties INTRODUCTION Pluronic F-127 (also known as Poloxamer 407 or PF-127) is a hydrophilic thermoreversible hydrogel system that has been used for drug delivery across diferent routes of administration. Feb 15, 2011 · In particular, Pluronic F127 or Poloxamer 407 has received much attention because of its unique thermo-reversible gelation properties that has found numerous pharmaceutical applications [4], [6]. Pluronic ® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and The preformulation and characterization studies were conducted to evaluate the incompatibilities among sorafenib, PLGA and pluronic F-127, and physicochemical properties of the formulations May 1, 2024 · Pluronic F-127 has been widely used as a coating or stabilizing agent for nanoparticle surface modification in various biomedical applications [23, 24]. Pharmaceutically, these systems are Pluronic F127 hydrogel biomaterial has garnered considerable attention in wound healing and repair due to its remarkable properties including temperature sensitivity, injectability, biodegradability, and maintain a moist wound environment. Physicochemical Properties Understanding the physicochemical properties of Pluronic F127 is crucial for its applications across various scientific domains. A unique characteristic of Pluronic F-127 is its thermosensitivity, which enables it to hold encapsulated cells in its structure and favors initial cell adhesion inside the defect site [26, 27]. Aug 7, 2023 · Pluronic F127 hydrogel biomaterial has garnered considerable attention in wound healing and repair due to its remarkable properties including temperature sensitivity, injectability, biodegradability, and maintain a moist wound environment. May 1, 2021 · Pluronic F-127 is a triblock copolymer (PEO-PPO-PEO) that can form a micelle at critical micelle concentration (CMC). Preparation and properties of pluronic F-127 gels for treatment of burns Jan 10, 2023 · Different formulations containing Pluronic F127 and polysaccharides (chitosan, sodium alginate, gellan gum, and κ-carrageenan) were investigated as potential injectable gels that behave as free-flowing liquid with reduced viscosity at low temperatures and displayed solid-like properties at 37 °C. Dec 1, 2022 · Pluronic-F127 and Click chemistry-based injectable biodegradable hydrogels with controlled mechanical properties for cell encapsulation Piyarat Sungkhaphan , Nuttapol Risangud , Weerawan Hankamolsiri , Pacharapan Sonthithai , Wanida Janvikul Show more Add to Mendeley Aug 12, 2019 · The Influence of Pluronic F68 and F127 Nanocarrier on physicochemical properties, in vitro release, and antiproliferative activity of thymoquinone drug. Feb 11, 2019 · Click chemistry is an effective tool to fabricate three-dimensional gel network in an accurate way. This work is focused on the production and characterization of AgNPs loaded in a Pluronic ® F127 hydrogel, as well as assessing its antimicrobial and wound-healing potential. Release of the model drugs has been shown to decrease with increasing poloxamer concentration which is probably due Aug 9, 2023 · Before describing the individual properties of Pluronics (F-68 and/or F-127), the keywords Pluronic F-68 and Pluronic F-127 were searched for in the literature. The macropores formed in the Pluronic samples were both smaller and less homogeneously distributed compared with the pores formed in the Tween samples. Administration of Pluronics formulations in the Aug 7, 2023 · Abstract Pluronic F127 hydrogel biomaterial has garnered considerable attention in wound healing and repair due to its remarkable properties including temperature sensitivity, injectability, biodegradability, and maintain a moist wound environment. Pluronic ® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. In addition, ZnO nanoparticles, lysozyme, or curcumin were added for testing the antimicrobial The intratumoral administration (in situ) of Pluronic ® F127 is an interesting pharmaceutical technology currently under evaluation for cancer treatment, which improves pharmacokinetic and pharmacodynamic properties, minimizes adverse effects, and enhances treatment efficacy [32]. This comprehensive review provides an in-depth exploration of the recent advancements in Pluronic F127-derived hydrogels, such as F127-CHO, F127-NH Jan 10, 2023 · The antimicrobial properties of Pluronic F127 gels are very modest even by adding chitosan, lysozyme, or ZnO nanoparticles. The bufalin-encapsulated cross-linked nanomicelles had a size distribution of 21 ± 3 nm with a spherical morphology. Its ability to form stable micelles, solubilize hydrophobic drugs, and exhibit thermosensitive behavior (such as forming gels at body temperature) are critical for its pharmaceutical applications. After successfully introducing both PDT and Pluronic® materials, we have provided a detailed discussion of the different types of Pluronics® available, based on their shape, size, and morphologies. The physical properties of a nonionic surfactant of 12,500 molecular weight, Pluronic F-127, are presented. Mar 22, 2016 · Biomimetic and photo crosslinked hyaluronic acid/pluronic F127 hydrogels with enhanced mechanical and elastic properties to be applied in tissue engineering Article Published: 22 March 2016 Volume 24, pages 282–291, (2016) Cite this article Download PDF Sang Soo Sohn, Vishnu Revuri, Md Nurunnabi, Kwang Soo Kwak & Yong-kyu Lee 894 Accesses 20 PLURONIC F-127* Block polyether F-127 information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook. Consequently, the historical evolution of Pluronic F127 reflects the broader trends in materials science, emphasizing research and development that bridge chemistry and practical application. Pluronic® F-127 *Cell culture tested * is manufactured by AAT Bioquest Sep 6, 2018 · The current research outcomes showed that not each polymer gel dosimeter could be manufactured with Pluronic F-127. The use of the operator “OR” broadens the search to include different variants of PF-127 and antimicrobial agents. 1,2 It is a thermosensitive, biocompatible, and bioabsorbable polymer with great prospects in tissue engineering applications. For the convenience, we also offer 20% Pluronic® F-127 DMSO solution (Cat. Its micellar properties and gelation behavior provide excellent residence capability which makes it suitable for the development of controlled drug delivery system. reported that aqueous solutions of poloxamer 188 (Pluronic F-68) and poloxamer 407 (Pluronic F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells. Sep 12, 2020 · We studied the thermogelation of a triblock copolymer Pluronic F127 (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)) in an aqueous solvent in the presence of gold nanoparticles, using pulsed field gradient diffusion, NMR temperature experiments, relaxation measurements, and 2D heteronuclear NMR experiments. CMC for Pluronic F-127 is 0. Pluronic F-127 (also known as Poloxamer 407 or PF-127) is a hydrophilic thermoreversible hydrogel system that has been used for drug delivery across different routes of administration. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. A remarkable enhancement of antimicrobial activity was observed in the presence of curcumin. Schmolka , “ Artificial skin I. [8 Jun 5, 2023 · Properties of Pluronic F68 and F127 micelles interacting furosemide from coarse-grained molecular simulations as validated by experiments Jul 15, 2020 · Pluronic F127 hydrogels are considered as good base for topical drug delivery applications because of their wound healing properties in rat and pig models [[88], [89], [90]]. , 2006; Chiappetta and Sosnik, 2007; Nanjawade et al. 5%) and polycarbophil (0. 3 PF-127 is a non-ionic surfactant made of ethylene oxide and propylene Dec 8, 2021 · Pluronic and materials based on it, due to its favorable properties are widely used in tissue engineering applications for creating scaffolds, cell, and drug delivery constructs or as a sacrificial material for bioprinting. Furthermore, Pluronic F-127 showed an important biological role in drug delivery where it plays a role in sensitizing multidrug-resistant cancer cells to the anti-cancer agents [25]. . [110] developed injectable hydrogels with thermosensitive properties based on hybrid chitosan-Pluronic F127 (CP) obtained by reacting chitosan with N-hydroxysuccinimide (NHS) and 1-ethyl-3- (3-dimethylaminopropyl)-carbodiimide (EDC). Mar 15, 2015 · Moreover, Pluronic F-127 hydrogel has favorable properties such as non-toxicity, biocompatibility, and biodegradability. The viscosity of Pluronic sols Hence, in this study, the influence of two different polymeric micelles of Pluronic F127- and F68-encapsulated TQ was evaluated toward the physicochemical properties, in vitro release, and antiproliferative effect. Both the mass fraction of F127DA and the Nov 11, 2024 · The physical and chemical properties of Pluronic ® F127 make it an ideal candidate for drug delivery. The antimicrobial properties of Pluronic F127 gels are very modest even by adding chitosan, lysozyme, or ZnO nanoparticles. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. It is also useful for isolation of membrane proteins. Pharmacogn. Pluronic ® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. [1] These properties make this polymer suitable for use as a versatile drug carrier. At low F127 loadings (0–35%), the plasticizing effect was dominant, and the elongation at break of zein composite film containing 35% F127 was about 8-fold higher than that of the zein film with 10% F127. [8 The physical properties of a nonionic surfactant of 12,500 molecular weight, Pluronic F-127, are presented. Apr 1, 2020 · Understanding structure-property relationships is critical for the development of new drug delivery systems. % of alumina. Herein, an injectable thermosensitive hydrogel was developed for a drug and cellular delivery system. Pluronic® F‐127 is most commonly used to disperse the acetomethyl (AM) esters as well as cell tracer dyes such as CFDA‐SE. 1,2 It is a thermosensitive, biocompatible, and bioabsorbable polymer with great prospects in tissue engineering applications. 0‒50 Gy). Micelles are lipid molecules that can arrange themselves in a spherical form in an aqueous solution with a hydrophobic core and hydrophilic shell. Pluronic micelles have many advantageous properties that include a relatively low in vivo toxicity and an appropriate size that restricts renal excretion. This Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. Pluronic® F‐127 promotes solubilization of water‐insoluble dyes and other materials in physiological medium. They provide the opportunity to deliver drugs from micelles in a spacial and temporal controlled manner with enhanced intracellular uptake via fluid-phase endocytosis rather than a passive diffusion. , 2007; Bromberg, 2008). Apr 25, 2023 · Pluronic-F-127-Passivated SnO 2 Nanoparticles Derived by Using Polygonum cuspidatum Root Extract: Synthesis, Characterization, and Anticancer Properties Plants (Basel). Oct 1, 1986 · Low toxicity, reverse thermal gelation and high drug loading capabilities, suggest that PF-127 gels have great potential as a drug delivery system. In this work, Pluronic F127 gels are prepared by thiol–ene click chemistry, utilizing double-bond end-capped Pluronic F127 (F127DA) and pentaerythritol tetras-mercaptopropionate (PETMP) as the starting materials and triethylamine as the catalyst. Appropriate controls should be per-formed to make cer tain that Pluronic® F-127 is not altering the membrane properties of the cell. 3390/plants12091760. A nonionic surfactant that is 100% active and relatively nontoxic. Chitosan addition to Pluronic/curcumin systems improves their viscoelasticity, antimicrobial activity, and stability in time. What properties of F127 do you think make it very popular? May 1, 2025 · Mechanical and rheological properties of Pluronic F127 based-hydrogels loaded with chitosan grafted with hyaluronic acid and propolis, focused to atopic dermatitis treatment Aug 1, 2023 · For example, Park et al. # 20053). From the Fig. Pluronic® F-127 may also be useful for dispersing other lipophilic probes. In this review, we discuss the properties and characteristics of PF-127 and Pluronic lecithin organogels (PLO), and present many examples and advantages of the application of these polymeric systems in topical and transdermal administration of drugs. Additionally Abstract This study was designed to combine the mucoadhesive property of Noveon and the thermosensitive property of Pluronic F-127 into one gel system. Preparation and properties of pluronic F‐127 gels for treatment of burns ,” Jan 26, 2016 · On the other hand, Pluronic ® F-127, a nonionic surfactant, is a polymer compatible with many different substances. The chemical structure, Dec 1, 2002 · We investigate the gelation of a poly (ethylene oxide)–poly (propylene oxide)–poly (ethylene oxide) copolymer, Pluronic ® F127, in mammalian cell culture medium for applications in tissue engineering and cell encapsulation. Jul 28, 2023 · This search query focuses on articles that mention the specific term “Pluronic F-127” and its modifications in conjunction with different keywords corresponding to different antimicrobial agents. These properties make this polymer suitable for use as a versatile drug carrier. I. g. 7% at 25 0C. Using Pluronic F 127 as the solution additive for PVC membrane presents a potential for creating low-cost antifouling ultrafiltration membranes. Pulsed field gradient diffusion NMR is a powerful technique to study Jan 27, 2025 · Hydrophobic modification alters the properties of Pluronic F127 to form micelles more efficiently and enhances its drug-loading capacity. Articles of Pluronic F-127 are included as well. The preparation of cold aqueous solutions of the F-127 solution, to which silver salts and other medicaments are then added, is described. Pluronic ® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and Of these systems, Pluronic F-127 (PF-127) provides the pharmacist with an excellent drug delivery system for a number of routes of administration and is compatible with many different substances. Pluronic ® F127 has been extensively explored for therapeutic applications mainly due to its appealing properties. There are so many Pluronic products, and many of them are thermoresponsive. In this paper, we propose an efficient approach for predicting key parameters to select hydrophobic groups for F127 modification prior to synthesis, in order to improve the Pluronic-F-127-Passivated SnO 2 Nanoparticles Derived by Using Polygonum cuspidatum Root Extract: Synthesis, Characterization, and Anticancer Properties Poloxamer 407 (Pluronic® F127, PEO 9 9–PPO 67 –PEO 9 9) is widely employed for drug delivery because it is reported to be non–toxic and can form gels at 25 ° C at a concentration of 20 wt% (Dumortier et al. Appropriate controls should be per-formed to make cer tain that Pluronic® F-127 is not altering the membrane properties of the cell. At high F127 For example, rheological properties of F68 micelles are modified depending on the type of binary (Pluronic/water and Pluronic/organic solvent) and ternary systems (Pluronic/organic solvent/water) formed, reflecting the changes of the F68 solution behavior. doi: 10. But one of them, F127, is much more researched than others. For the convenience of our customers, Invitrogen offers Pluronic® F-127 in three forms as shown in Table 1. 5-2. Feb 2, 2025 · Figure 5 a shows the viscosity versus shear rate of Pluronic F-127, and Fig. [8 Pluronic ® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. Appropriate controls should be performed to make certain that Pluronic® F-127 is not altering the membrane properties of the cells. wvjsmhlf2ie8j4nou30ngrbqhfsoq8doyjn7lisnac7khvvlskmb